Heart & Circulation

The exact reasons for the age-related decrease in testosterone levels are unknown. It is probably due to a combination of factors including an increase in body fat mass (and an associated increase in aromatase activity), oxidative damage to testosterone-producing tissues and a decline in precursor molecules such as DHEA. A...

Left ventricular ischemic diastolic dysfunction is a cause of heart failure. Congestive heart failure occurs when the heart no longer pumps efficiently enough to provide the body with freshly-oxygenated blood. Endothelial dysfunction, described as a malfunction of the cells which line the blood vessels, plays a key role in the...

A study investigated the cardio-protective role of two antioxidants: melatonin and alpha-lipoic acid. Melatonin is a hormone secreted by the pineal gland which regulates the sleep-wake cycle and also has a significant antioxidant effect. Alpha lipoic acid is unique as an antioxidant in that it is both fat- and water-soluble...