Celadrin® fights inflammation naturally

Celadrin® is a natural compound, developed through a proprietary process of esterifying oils, which has been clinically shown to reduce inflammation and pain. It comprises a patented blend of esterified fatty acid carbons: myristic, myristoleic, oleic, palmitoleic, palmitic, lauric, decanoic and stearic acids. Celadrin® reduces inflammation, lubricates cell membranes and restores integrity of the fluids protecting bones and joints. It also helps reduce degeneration of cartilage. It is faster-acting than other natural ingredients, and has none of the side effects of anti-inflammatory drugs.

During an inflammatory response, membrane phospholipids get broken down into arachidonic acid by the action of phospholipase A2. Leukotrienes and prostaglandins derived from phospholipase-released arachidonic acid are then generated by lipoxygenase and cyclooxygenase respectively. Prostaglandins increase capillary permeability and maximise the response to other inflammatory mediators, and thus play a key role in the process of inflammation.

Protects cell membranes

Cell membranes separate and protect cell components from neighbouring cells and the outside world. Some of the major components of cell membranes are structural lipids which regulate nutrients, minerals, electrolytes, drugs and other compounds across the cell membrane.
There are innumerable stressors that target and impair these lipids, resulting in damage to the cell membrane, and even cell death.
Loss of cell membrane integrity as a result of internal or external stressors marks the start of a number of rapid ageing processes, including uncontrolled or unbalanced inflammation.
Celadrin® provides the perfect combination of lipids for improving and boosting cell membrane function and integrity. By strengthening the membrane’s lipid structure, it promotes cell repair and regeneration.

Inhibits generation of inflammatory mediators

Epidemiological and clinical studies suggest that supplementing with omega-3 fatty acids (EPA/DHA) brings benefits to sufferers of rheumatoid arthritis, with the effects of such long-chain omega-3s comparable to those of certain anti-inflammatory drugs which inhibit production of inflammatory mediators. However, few studies have been conducted on the benefits of fish oils for osteoarthritis. Such benefits are predicated on the fact that the fatty acids in fish oils alter membrane phospholipids and reduce generation of inflammation-inducing eicosanoids. Fish oils also decrease cytokine production and cell activation.
A study on rats has also shown that monounsaturated fatty acids (such as myristoleic acid) may provide protection against adjuvant-induced arthritis. While the mechanism of action is unclear, research indicates that myristoleic acid may act by inhibiting 5-lipoxygenase, a powerful mediator of inflammation and allergic reactions¹. For the last 20 years, 5-lipooxygenase products have been associated with the inflammatory processes that lead to joint destruction in rheumatoid arthritis. Celadrin® acts in a similar way to EPA and DHA in fish oils but has a more powerful effect.

Improves mobility

The results of a double-blind, placebo-controlled, multi-centre study, published in the prestigious Journal of Rheumatology, show that orally-administered Celadrin® improves joint and mobility problems. Conducted in two clinics in the Indian city of Bangalore, the study examined the benefits of a complex of monounsaturated cetylated fatty acids among patients with arthritis of the knee.
Sixty-four subjects aged 37-77 received six capsules of Celadrin® a day or placebo, divided into morning and evening doses. Their condition was assessed at baseline, after 30 days and at the end of the 68-day study.
Compared with controls, those taking Celadrin® were found to have greater flexibility and less pain, and could walk longer distances.
The effects of Celadrin® on knee osteoarthritis were comparable to those obtained with widely-used medications. The researchers summarised their findings as follows: the use of a complex of cetylated fatty acids produced improvements in a range of movements and functions in patients suffering from arthritis of the knee for 5-6 years. Additional studies are needed to establish whether the cetylated fatty acids alter the 5-lipooxygenase enzyme through either substrate or inhibitory mechanisms and whether they influence leukotriene production².

Efficacy of topical Celadrin® on osteoarthritis of the knee

Forty patients with arthritis in one or both knees were randomly divided into two groups, and treated with a cream containing either cetylated fatty acids or a placebo. Tests were carried out at the start of the study, 30 minutes after application and 30 days post-treatment.
The researchers evaluated functional mobility, postural stability, pain and various types of movement, including ability to get up from a chair and climb stairs, endurance and range of motion in the knee. Results for those treated with Celadrin® were remarkable – 100% experienced considerable benefits compared with controls, including reductions in pain and stiffness, and improvements in strength, balance and mobility. Especially noteworthy was the fact that significant improvements across all aspects were felt just 30 minutes after application of the cream, with cumulative benefits reported after 30 days’ treatment ³.
A further study added weight to these findings. It showed improvements in mobility of the shoulder, wrist and knee as well as a significant reduction in pain.
Scientists at the University of Connecticut conducted a double-blind, placebo-controlled study on 40 patients with osteoarthritis of the knee, testing the effects of a cream containing cetylated fatty acids on static postural stability and plantar pressure distribution.
Subjects applied a cream, twice daily for 30 days, that contained either Celadrin® or a placebo, with their condition assessed at baseline and at the end of the treatment period. Results suggested that the cream containing cetylated fatty acids improved static postural stability, probably by relieving pain⁴.

Well absorbed orally and topically

An animal study carried out at the University of Minnesota showed that the cetylated fatty acids in Celadrin® are well absorbed when administered orally or topically. While a small percentage remain intact, the majority are hydrolysed and the cetyl alcohol is metabolised into fatty acids and esterified in various types of lipid such as phospholipids, triglycerides and cholesterol esters⁵.

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1. Bonnet C. et al., Lipoxygenase products and expression of 5-lipoxygenase activing protein in human cultured synovial cells, Prostaglandins, 1995, 50: 127-35.
2. Hesslink R. Jr et al., Cetylated fatty acids improve knee function in patients with osteoarthritis, J. Rheumatol., 2002, 29: 1708-12.
3. Kraemer W.J. et al., Effect of cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis, J. Rheumatol., 2004, 31: 767-74.
4. Kraemer W.J. et al., Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis, Journal of Strength and Conditioning Association, 2005, 19(1): 115-121.
5. Gallaher D.D., Distribution of cetylated fatty acids in rats after oral or topical administration, Federation of American Societies of Experimental Biology Journal, 2002.