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04-02-2019

CBD: why the whole world’s snapping it up

CBD

If you’re interested in nutrition, you can’t have failed to notice the rise of CBD. This 100% natural cannabinoid is a massive hit across the world! Free from adverse side-effects and completely legal, it’s bringing happiness to millions of victims of chronic pain, anxiety and sleep problems. Now, according to a new study, it could deliver even more.


A team of researchers recently investigated the anti-proliferative effects of CBD, already demonstrated in previous studies. They concluded that cannabinoids may be able to stem cancer progress by preventing diseased cells from dividing and invading healthy tissue. Other studies have also suggested that cannabinoids may deprive tumours of the blood supply they need to grow, and may stimulate the immune response. “There is still a need for additional anti-cancer substances,” said study author Professor Burkhard Hinz. “ If we summarise all the existing data on cannabinoids, we can see that they act at several levels of cancer progression.” This significant new property adds to CBD’s most remarkable effect - one which is undoubtedly easier to observe: that of providing rapid pain relief.

How does CBD relieve chronic pain?

Several studies had previously demonstrated CBD’s ability to make pain more tolerable and less unpleasant but had been unable to explain the precise mechanism involved (1). But as of the end of 2018, the scientific community has been onto something. Dr Gabriella Gobbi and her team have shown that CBD does not act on the cannabinoid receptors called CB1 like THC, but acts instead through a mechanism that binds specific receptors involved in anxiety (serotonin 5-HT1A) and pain (vanilloid TRPV1).


In animal models of neuropathic or chronic pain, we found that low doses of CBD, administered for seven days, relieved both pain and anxiety, two symptoms often associated,” said study author Danilo De Gregorio. “Our research has elucidated the mechanism of action of CBD, added Dr Gobbi, and it shows that it could be used without the significant side-effects of THC!”


This represents a major advance in our understanding of phytocannabinoids - compounds which offer new options for relieving back pain, joint pain, and pain associated with trauma …

How should CBD be taken?

CBD is a lipophilic compound, which means it tends to dissolve in fats. Its absorption across the intestinal wall is significantly affected by this characteristic: absorption is increased five-fold if you take it with a high-fat meal rather than on an empty stomach or between meals (2). Fats also stimulate the secretion of bile in the intestines which improves absorption of CBD.


It’s worth noting that after ingesting a capsule of CBD 25mg it takes around three hours for blood levels to peak. And the effects can last for 24-48 hours (3)!


If you’ve not yet found a natural compound that provides relief without causing adverse side-effects, you now know what you need to do …


The two studies

1. Burkhard Hinz Robert Ramer. Anti‐tumoural actions of cannabinoids. British Journal of Pharmacology, 2018 DOI: 10.1111/bph.14426

2. Danilo De Gregorio, Ryan J. McLaughlin, Luca Posa, Rafael Ochoa-Sanchez, Justine Enns, Martha Lopez-Canul, Matthew Aboud, Sabatino Maione, Stefano Comai, Gabriella Gobbi. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. PAIN, 2018; 1 DOI: 10.1097/j.pain.0000000000001386


Additional references

3. De Vita et al. Association of Cannabinoid Administration With Experimental Pain in Healthy Adultsy. (2018). JAMA Psychiatry.doi:10.1001/jamapsychiatry.2018.2503

4. FDA – Epidiolex labeling revised 6/2018 - https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210365lbl.pdf

5. Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., … Wright, S. (2017). Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. New England Journal of Medicine, 376(21), 2011–2020.doi:10.1056/nejmoa1611618

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